Vaccines, and their discovery, are topics of singular importance in present-day biomedical science. The discovery of vaccines has hitherto been primarily empirical in nature, and it is only now that this is giving way, albeit very slowly, to a more rational approach, supported and enhanced by computer-based methods. In this context, the book "Computer-Aided Vaccine Design" by Tong and Ranganathan is a welcome new addition to the growing list of biomedical texts that address the computational discovery of vaccines and their components.