
doi: 10.4161/cc.9.2.10567
pmid: 20023377
This division of labor is thought to contribute to the hypergly-cemia (inhibition of IRS2 signaling) and the paradoxical lipid accumulation (sus-tained IRS1 signaling) in type 2 diabetes. Regardless, recent work with genetically modified mice shows that both IRS1 and IRS2 are strong inhibitors of FoxO1,
Forkhead Box Protein O1, Gluconeogenesis, Membrane Proteins, Forkhead Transcription Factors, Lipid Metabolism, NAD, Mice, Liver, Animals, Insulin Resistance, Heme Oxygenase-1, Signal Transduction
Forkhead Box Protein O1, Gluconeogenesis, Membrane Proteins, Forkhead Transcription Factors, Lipid Metabolism, NAD, Mice, Liver, Animals, Insulin Resistance, Heme Oxygenase-1, Signal Transduction
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