Paths of FGFR-driven tumorigenesis
Copyright policy )Paths of FGFR-driven tumorigenesis
Fibroblast growth factor receptors (FGFRs) comprise a subfamily of receptor tyrosine kinases (RTKs) that are master regulators of a broad spectrum of cellular and developmental processes, including apoptosis, proliferation, migration and angiogenesis. Due to their broad impact, FGFRs and other RTKs are highly regulated and normally only basally active. Deregulation of FGFR signaling by activating mutations or ligand/receptor overexpression could allow these receptors to become constitutively active, leading to cancer development, including both hematopoietic and solid tumors, such as breast, bladder and prostate carcinomas. In this review, we focus on potential modes of FGFR-mediated tumorigenesis, in particular, the role of FGFR1 during prostate cancer progression.
- Baylor College of Medicine United States
- BAYLOR COLLEGE OF MEDICINE
Male, Neovascularization, Pathologic, Gene Expression Profiling, Prostatic Neoplasms, Epithelial Cells, Cell Communication, Protein-Tyrosine Kinases, Receptors, Fibroblast Growth Factor, Gene Expression Regulation, Neoplastic, Receptors, Androgen, Disease Progression, Animals, Humans, Protein Isoforms, Stromal Cells, Signal Transduction
Male, Neovascularization, Pathologic, Gene Expression Profiling, Prostatic Neoplasms, Epithelial Cells, Cell Communication, Protein-Tyrosine Kinases, Receptors, Fibroblast Growth Factor, Gene Expression Regulation, Neoplastic, Receptors, Androgen, Disease Progression, Animals, Humans, Protein Isoforms, Stromal Cells, Signal Transduction
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