descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2009 English Publisher:Informa UK LimitedJournal:Cell Cycle, volume 8, pages 2,041-2,049 (issn: 1538-4101, eissn: 1551-4005,

Authors: Robert, Kob; Juliane, Kelm; Nicole, Posorski; Aria, Baniahmad; Ferdinand, von Eggeling; Christian, Melle;

doi: 10.4161/cc.8.13.8850

pmid: 19535905

Regulation of the anaphase-promoting complex by the COP9 signalosome

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Abstract

The COP9 complex (signalosome) is a known regulator of the proteasome/ubiquitin pathway. Furthermore it regulates the activity of the cullin-RING ligase (CRL) families of ubiquitin E3-complexes. Besides the CRL family, the anaphase-promoting complex (APC/C) is a major regulator of the cell cycle. To investigate a possible connection between both complexes we assessed interacting partners of COP9 using an in vivo protein-protein interaction assay. Hereby, we were able to show for the first time that CSN2, a subunit of the COP9 signalosome, interacts physically with APC/C. Furthermore, we detected a functional influence of the COP9 complex regarding the stability of several targets of the APC/C. Consistent with these data we showed a genetic instability of cells overexpressing CSN2.

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Keywords

Repressor Proteins, COP9 Signalosome Complex, Cell Line, Tumor, Multiprotein Complexes, Humans, Ubiquitin-Protein Ligase Complexes, Apoptosis, Anaphase-Promoting Complex-Cyclosome, Genomic Instability, Peptide Hydrolases

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cDNA, FLJ93029, highly similar to Homo sapiens COP9 constitutive photomorphogenic homolog subunit 2
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COP9 signalosome complex subunit 2
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COP9 constitutive photomorphogenic homolog subunit 2 variant
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COP9 signalosome complex subunit 2
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