The Road to Survival Goes through PARG
Copyright policy )The Road to Survival Goes through PARG
Unlike poly(ADP-ribose) polymerase-1 (PARP-1), poly(ADP-ribose) glycohydrolase (PARG) has long been a difficult protein to study. However, the complete absence of PARG activity was recently characterized in mice via disruption of the murine PARG gene. As expected, PARG is critical for the maintenance of steady-state poly(ADP-ribose) levels. But surprisingly, the disruption of PARG led to embryonic lethality and increased susceptibility to mild cell stress. Therefore, the protective role of PARG and its involvement in development indicate that these roads to viability go through PARG.
- Johns Hopkins University School of Medicine United States
- Johns Hopkins Medicine United States
Glycoside Hydrolases, Cell Survival, Polymers, Cell Cycle, Mice, Transgenic, Models, Biological, Mice, Gene Expression Regulation, Mutation, Animals, DNA Damage
Glycoside Hydrolases, Cell Survival, Polymers, Cell Cycle, Mice, Transgenic, Models, Biological, Mice, Gene Expression Regulation, Mutation, Animals, DNA Damage
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).20 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!