Are p27 and p21 Cytoplasmic Oncoproteins?
Copyright policy )Are p27 and p21 Cytoplasmic Oncoproteins?
By causing cytoplasmic mislocation of p27 and p21, the Akt oncogenic kinase functionally inactivates these nuclear tumor suppressor proteins. Is cytoplasmic localization of p27 and p21 simply equivalent to loss of their function or are new functions acquired in the cytoplasm? Indeed, several lines of evidence suggest that cytoplasmic p27 and p21 may be oncoproteins with antiapoptotic activities.
- Cancer Research Institute United States
Cell Nucleus, Cyclin-Dependent Kinase Inhibitor p21, Cytoplasm, Tumor Suppressor Proteins, Cell Cycle, Apoptosis, Cell Cycle Proteins, Cell Compartmentation, Cell Transformation, Neoplastic, Cyclins, Neoplasms, Animals, Humans, Cyclin-Dependent Kinase Inhibitor p27
Cell Nucleus, Cyclin-Dependent Kinase Inhibitor p21, Cytoplasm, Tumor Suppressor Proteins, Cell Cycle, Apoptosis, Cell Cycle Proteins, Cell Compartmentation, Cell Transformation, Neoplastic, Cyclins, Neoplasms, Animals, Humans, Cyclin-Dependent Kinase Inhibitor p27
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