When to screen and not to screen
Copyright policy )When to screen and not to screen
Colorectal cancer (CRC) is the third most common cause of cancer-related deaths with treatment of advanced and metastatic CRC (mCRC) remaining palliative at best. (1) The epidermal growth factor receptor (EGFR) has been identified as a therapeutic target for a multitude of malignancies, including mCRC. Ligand-binding to EGFR results in the subsequent activation of multiple signal transduction pathways including the PI3K/AKT and RAS/RAF/MAPK pathways, which are vital for cell growth and survival. (2) Constitutive activation of these signaling pathways leads to deregulated cellular proliferation, malignant progression, and invasion. (3.)
- Virginia Commonwealth University United States
Male, Antibodies, Monoclonal, Antineoplastic Agents, ErbB Receptors, Proto-Oncogene Proteins, Commentary, ras Proteins, Humans, Female, Colorectal Neoplasms
Male, Antibodies, Monoclonal, Antineoplastic Agents, ErbB Receptors, Proto-Oncogene Proteins, Commentary, ras Proteins, Humans, Female, Colorectal Neoplasms
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).3 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!