VEGF-initiated angiogenesis and the uPA/uPAR system
Copyright policy )VEGF-initiated angiogenesis and the uPA/uPAR system
Angiogenesis involves a series of tightly regulated cellular processes initiated primarily by the vascular endothelial growth factor (VEGF). The urokinase-type plasminogen activator system, consisting of the urokinase-type plasminogen activator (uPA), its cellular receptor uPAR and its inhibitor PAI-1, participates in the realization of these VEGF-induced processes by activating pericellular proteolysis, increasing vascular permeability and by supporting endothelial cell proliferation and migration.
- Medical University of Vienna Austria
Vascular Endothelial Growth Factor A, Neovascularization, Pathologic, MAP Kinase Signaling System, Endothelial Cells, Urokinase-Type Plasminogen Activator, Receptors, Urokinase Plasminogen Activator, Capillary Permeability, Enzyme Activation, Mice, Cell Movement, Plasminogen Activator Inhibitor 1, Protein Interaction Mapping, Proteolysis, Animals, Humans, Integrin alpha Chains, Cell Proliferation, Protein Binding
Vascular Endothelial Growth Factor A, Neovascularization, Pathologic, MAP Kinase Signaling System, Endothelial Cells, Urokinase-Type Plasminogen Activator, Receptors, Urokinase Plasminogen Activator, Capillary Permeability, Enzyme Activation, Mice, Cell Movement, Plasminogen Activator Inhibitor 1, Protein Interaction Mapping, Proteolysis, Animals, Humans, Integrin alpha Chains, Cell Proliferation, Protein Binding
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