How a common variant in the growth factor receptor gene,NTRK1, affects white matter
Copyright policy )How a common variant in the growth factor receptor gene,NTRK1, affects white matter
Growth factors and their receptors are important for cellular migration as well as axonal guidance and myelination in the brain. They also play a key role in programmed cell death, and are implicated in a number of mental illnesses. Recently, we reported that healthy young adults who carry the T allele variant in the growth factor gene, NTRK1 (at location rs6336), had lower white matter integrity than non-carriers on diffusion images of the brain. Diffusion tensor imaging (DTI) revealed how this single nucleotide polymorphism affects white matter microstructure in human populations; DTI is also used to identify characteristic features of brain connectivity in typically developing children and in patients. Newly discovered links between neuroimaging measures and growth factors whose molecular neuroscience is well known offer an important step in understanding mechanisms that contribute to brain connectivity. Altered fiber connectivity may mediate the relationship between some genetic risk factors and a variety of mental illnesses.
- University of Queensland Australia
- QIMR Berghofer Medical Research Institute Australia
- University of Queensland Australia
- University of California, Los Angeles United States
- University of Queensland Australia
genetic association, growth factor receptor, genetic risk, 1307 Cell Biology, myelin sheath, Neurotrophic tyrosine kinase receptor 1, 1315 Structural Biology, single nucleotide polymorphism, Leukoencephalopathies, genetic variability, genetics, neuroimaging, article, risk assessment, gene expression regulation, Growth factor, White Matter, genetic code, receptor gene, Diffusion tensor imaging, 2700 Medicine, Myelin, trkA, Tropomyosin-related kinase receptor A, Neurotrophin, white matter, signal transduction, Receptor, leukoencephalopathy, gene locus, neuroanatomy, Short Communication, brain region, Development, protein tyrosine kinase A, Humans, human, Receptor, trkA, missense mutation, Genetic Variation, heterozygote, Radial diffusivity, neurotrophic tyrosine kinase receptor 1 gene, Schizophrenia, pathology, cortical thickness (brain), metabolism, Fractional anisotropy
genetic association, growth factor receptor, genetic risk, 1307 Cell Biology, myelin sheath, Neurotrophic tyrosine kinase receptor 1, 1315 Structural Biology, single nucleotide polymorphism, Leukoencephalopathies, genetic variability, genetics, neuroimaging, article, risk assessment, gene expression regulation, Growth factor, White Matter, genetic code, receptor gene, Diffusion tensor imaging, 2700 Medicine, Myelin, trkA, Tropomyosin-related kinase receptor A, Neurotrophin, white matter, signal transduction, Receptor, leukoencephalopathy, gene locus, neuroanatomy, Short Communication, brain region, Development, protein tyrosine kinase A, Humans, human, Receptor, trkA, missense mutation, Genetic Variation, heterozygote, Radial diffusivity, neurotrophic tyrosine kinase receptor 1 gene, Schizophrenia, pathology, cortical thickness (brain), metabolism, Fractional anisotropy
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