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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Therapeutic Delivery
Article . 2012 . Peer-reviewed
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Thermoresponsive Hydrogels for Cellular Delivery

Authors: CELLESI, FRANCESCO;

Thermoresponsive Hydrogels for Cellular Delivery

Abstract

The delivery of living cells into a host body has emerged as a promising approach to treating a variety of different diseases and for tissue repair. However, one of the major obstacles for clinical success is to deliver the cells to the target tissue without losing control of cell fate and function after transplantation. Temperature-responsive biomaterials represent a promising vehicle to deliver cells noninvasively by injection of a liquid precursor, which undergoes a reversible phase transition at body temperature, thus, forming temperature-induced hydrogels in situ. The final material provides transplanted cells with a synthetic extracellular matrix, which retains the cells at the injection site, supports cell growth and mitigates migration. This mini review is intended to cover the fundamental physicochemical characteristics of these thermoresponsive biomaterials, and to examine the applications, with a focus on the recently developed cell-delivery systems for tissue engineering and cell therapy, including advantages, limitations and future challenges.

Country
Italy
Related Organizations
Keywords

Chitosan, Drug Delivery Systems, Tissue Engineering, Polymers, Temperature, Animals, Humans, Hydrogels, Poloxamer

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
26
Top 10%
Top 10%
Top 10%
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