Orexin Receptor Antagonists
Copyright policy )Orexin Receptor Antagonists
The orexin neuropeptides bind to two G protein-coupled receptors, orexin-1 and -2. Small-molecule antagonism of the receptors has potential therapeutic utility in a number of areas, most notably insomnia, for which the most advanced dual orexin receptor antagonist has now completed clinical trials. The purpose of this article is to comprehensively review small-molecule orexin antagonist patent activity during the period 2009-2011.
Clinical Trials as Topic, Orexins, Neuropeptides, Intracellular Signaling Peptides and Proteins, Patents as Topic, Drug Design, Sleep Initiation and Maintenance Disorders, Animals, Humans, Hypnotics and Sedatives, Orexin Receptor Antagonists
Clinical Trials as Topic, Orexins, Neuropeptides, Intracellular Signaling Peptides and Proteins, Patents as Topic, Drug Design, Sleep Initiation and Maintenance Disorders, Animals, Humans, Hypnotics and Sedatives, Orexin Receptor Antagonists
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).14 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
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