Photosensitizers Binding to Nucleic Acids as Anticancer Agents

descriptionPublicationkeyboard_double_arrow_right Article 25 Jan 2016 Italy English Publisher:Informa UK LimitedJournal:Future Medicinal Chemistry, volume 8, pages 179-194 (issn: 1756-8919, eissn: 1756-8927,

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Authors: XODO, Luigi; Cogoi, Susanna; RAPOZZI, Valentina;

doi: 10.4155/fmc.15.180

pmid: 26807879

handle: 11390/1093784

Photosensitizers Binding to Nucleic Acids as Anticancer Agents

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Abstract

Cationic porphyrins (Prs) and phthalocyanines (Pcs) are strong photosensitizers that have drawn much attention for their potential in photodynamic therapy. These compounds have the interesting property of binding to nucleic acids, in particular G-rich quadruplex-forming sequences in DNA and RNA. In this review, we highlight their potential as anticancer drugs.

Country

Italy

Related Organizations

University of Udine
Italy

Keywords

B78-H1; cancer; cationic phthalocyanines; cationic porphyrins; KRAS; mRNA suppression; Panc-1; photodynamic therapy; RNA-quadruplexes; singlet oxygen; Animals; Antineoplastic Agents; DNA; G-Quadruplexes; Humans; Indoles; Neoplasms; Photochemotherapy; Photosensitizing Agents; Porphyrins; RNA, Messenger; ras Proteins; Drug Discovery3003 Pharmaceutical Science; Pharmacology; Molecular Medicine; Medicine (all), Indoles, Photosensitizing Agents, Porphyrins, Antineoplastic Agents, DNA, Isoindoles, G-Quadruplexes, Photochemotherapy, Neoplasms, ras Proteins, Animals, Humans, RNA, Messenger

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