Microextraction by packed sorbent (MEPS) is a miniaturized form of SPE. MEPS can handle small sample volumes and be connected on-line with LC or GC without any modifications. In addition, the MEPS sorbent bed is integrated into an injection syringe and can be used for more than 100 extractions. The key aspect of MEPS is that the solvent volume used for the elution of the analytes is of a suitable order of magnitude to be injected directly into GC or LC systems. MEPS has been used in many research fields such as environmental, biological and food analysis. This article gives an overview of the MEPS technique, including fields of application and common formats.