The synergistic antiviral effects of GSH in combination with acyclovir against BoHV-1 infection in vitro

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2016Publisher:Frontiers Media SAJournal:Acta virologica, volume 60, pages 328-332 (eissn: 1336-2305,

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Authors: Ch, Yuan; X, Fu; L, Huang; Y, Ma; X, Ding; L, Zhu; G, Zhu;

doi: 10.4149/av_2016_03_328

pmid: 27640443

The synergistic antiviral effects of GSH in combination with acyclovir against BoHV-1 infection in vitro

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Abstract

We have recently reported that bovine herpesvirus 1 (BoHV-1)-induced overproduction of reactive oxygen species (ROS) partially depends on NADPH oxidases (Noxs). In this study, we found that the decreased levels of main intracellular non-enzymatic antioxidant glutathione (GSH) during BoHV-1 infection also contributed to ROS production. Exogenous GSH administration dramatically inhibited BoHV-1 replication, indicating the critical role of decreased GSH for BoHV-1 replication. Interestingly, GSH synergistically enhanced the antiviral effects of acyclovir (ACV) against BoHV-1 infection in vitro. This study not only illuminates the effect of GSH on BoHV-1 infection but also provides evidence that pharmacological modulation of GSH-mediated ROS production in combination with specific antiviral drugs is a viable therapeutic approach to fighting virus infection.

Related Organizations

Yangzhou University
China (People's Republic of)

Keywords

Dose-Response Relationship, Drug, Acyclovir, Drug Synergism, Virus Replication, Antiviral Agents, Glutathione, Madin Darby Canine Kidney Cells, Dogs, Animals, Drug Therapy, Combination, Herpesvirus 1, Bovine

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