Amantadine-resistant influenza A (H3N2) viruses in Iran

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2009Publisher:Frontiers Media SAJournal:Acta Virologica, volume 53, pages 135-138 (eissn: 1336-2305,

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Authors: Yavarian, J.; Azad, T.; Jandaghi, N.; Nategh, R.;

doi: 10.4149/av_2009_02_135

pmid: 19537916

Amantadine-resistant influenza A (H3N2) viruses in Iran

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Abstract

Adamantanes have been used for the prophylaxis and treatment of Influenza A virus (IAV) infections worldwide. However, they have limited use because of increasing number of resistant viruses during recent years. In investigating the frequency of amantadine-resistant IAVs (H3N2) circulating in Iran in 2005-2008, we found that M2 sequences of recently circulating viruses that were amantadine-resistant contained a Ser31Asn mutation. Thus, adamantanes should not be used for treatment or prophylaxis of recent IAVs (H3N2) infections. In future, their potential use will depend on the resistance of circulating viruses.

Related Organizations

Tehran University of Medical Sciences
Iran (Islamic Republic of)

Keywords

Reverse Transcriptase Polymerase Chain Reaction, Influenza A Virus, H3N2 Subtype, Molecular Sequence Data, General Medicine, Microbial Sensitivity Tests, Sequence Analysis, DNA, Iran, Antiviral Agents, Viroporin Proteins, Viral Matrix Proteins, Infectious Diseases, Virology, Drug Resistance, Viral, Influenza, Human, Mutation, Amantadine, Humans, Phylogeny

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