One Health is a multisectoral cooperative and collaborative approach aimed at achieving integrated health by recognizing the interconnectedness of people, animals, plants, and the environment. In the modern world, the One Health approach is considered an essential perspective for overcoming various emerging diseases, including antimicrobial resistance (AMR). One of the top priority AMR infections is caused by carbapenem-resistant Enterobacterales (CRE), which are bacterial strains not susceptible to carbapenems, the last-resort antibiotics for clinical Gram-negative bacterial infections. Although carbapenems are not allowed to use in animals in the global community, various types of CRE are being reported among animals, including the carbapenemase-producing Enterobacterales (CPE). Therefore, since the dissemination and clinical infection of CPE represent a shared health threat, measures to raise awareness of this issue should be considered from the perspective of the One Health approach.