Chemical leukoderma is characterized by the development of acquired vitiligo-like hypo- to depigmented macules due to persistent or negligent chemical use. Sulfhydryl and potent phenol/catechol compounds are included in the etiology. The incidence of chemical leukoderma has been increasing in developing countries like India due to inadequate monitoring of the indiscriminate use of over-the-counter dermatological products. Here, we present a unique instance of chemical leukoderma subsequent to hydroquinone in a 37-year-old male.