Background: Pelvic inflammatory disease (PID) is a clinical syndrome that has the wide range of infections and inflammatory diseases of the upper female genital tract. Microbiological researches revealed that multiple bacteria have been identified as causative agents and several types of antibiotics are required to cover causative pathogens. The choice of an appropriate treatment mostly depended on antimicrobial sensitivity tests. Objectives: The present study aims to investigate the compatibility between the prescribed antibiotics given to patients with PIDs based on the clinical features with microbial sensitivity tests. Materials and Methods: The present study included 70 patients who attend Amedy hospital in Duhok province and screened for PIDs based on the clinical features. Due to the lack of antimicrobial-sensitivity culture tests, the patients are treated according to the standard treatment. The clinician records the clinical features of each patient with their prescribed drugs and antibiotics and takes an endocervical swab of each patient. These swabs are undergone microbial sensitivity tests for drug resistance. Results: The results revealed that 62.86% of patients were positive for the infection pathogens. There were 13 bacterial isolates of Staphylococcus aureus as the most commonly isolated organism in (29.55%) of cases followed by Candida specious (25%) and Streptococcus pyogenes (15.1%) with one case of Escherichia coli (2.27%). Seven antibiotic and antifungal drugs were the most prescribed antibiotics to patients with PIDs. Conclusions: The results of our study concluded that treating PIDs according to the standard treatment and based on clinical symptoms only is limited to coverage these diseases. Additional clinical and microbial sensitivity test are required before prescribed antibiotics or antifungal to patients with PIDs.