Background: Dental implants have an important role in mainstream dental practice today to restore esthetics. The present study was conducted to evaluate the microleakage at implant abutment and prosthesis interface in cemented implant-supported prosthesis. Materials and Methods: The present study comprised sixty replicas of abutment analog with length 5 mm, width of platform 4.8 mm, and taper 6° which were milled and divided into three groups. In Group I, nickel–chromium copings were fabricated; marginal gap was evaluated with optical microscope and luted with zinc oxide noneugenol cement, Group II with zinc polycarboxylate cement, and Group III with zinc phosphate cement. Microleakage was scored by the method used by Tjan et al. Results: The mean microleakage score in Group I was 2.5, in Group II was 1.9, and in Group III was 1.05. The difference was significant (P < 0.05). Conclusion: All cements showed microleakage. Minimum microleakage was seen with zinc phosphate cement than zinc oxide noneugenol cement and zinc polycarboxylate cement.