ABSTRACT Salmonella typhi (S. typhi) and Salmonella paratyphi A (S. paratyphi A), together known as typhoidal Salmonella, are causal agents for an invasive, serious, and sometimes fatal disease of humans called typhoid fever or paratyphoid fever (also known as enteric fever). S. Typhi, the lineage causing typhoid fever, is the main group; whereas S. Paratyphi A, the lineage causing paratyphoid fever, belongs to the second group, which comprises a set of three paratyphoid types (the other two being S. Paratyphi C and d-tartrate-negative S. Paratyphi B). All these lineages are adapted to humans, with S. Typhi and S. Paratyphi A being strictly restricted to growth in humans, and S. Paratyphi C being able to establish infections in experimental animals quite easily (at moderate infection doses); the host-restriction status of d-tartrate-negative S. Paratyphi B is so far unclear. The potential source of infection is the use of sewage-contaminated water in plants and vegetable irrigation and clinical presentation is varied, mainly presenting with fever, malaise, abdominal discomfort, and nonspecific symptoms often confused with other causes of the febrile syndrome. S. Paratyphi is usually a mild form of disease without any complication, but we report a complicated case of Paratyphi, who presented with fever and gastrointestinal symptoms complicated by multiorgan dysfunction needing mechanical ventilatory support, multiple hemodialysis, and blood transfusion. Fortunately, he recovered from all the insults and was discharged home in stable condition on the 26th day of hospitalization.