Pleurodesis is a procedure which obliterates the pleural cavity with the intent of preventing reaccumulation of fluid or air in the pleural cavity. The common indications for performing pleurodesis include malignant pleural effusions and recurrent pneumothorax. Various techniques to perform pleurodesis have been described in the literature. Pleurodesis can be classified as chemical pleurodesis, where in a chemical sclerosant is introduced into the pleural cavity, or mechanical pleurodesis, where in physical abrasion of the pleura is performed during a pleuroscopic intervention. It is important for practicing pulmonary physicians to be abreast with the techniques of performing pleurodesis and its possible complications. The current review article describes the indications of pleurodesis, the technique of performing pleurodesis, possible complications postpleurodesis and their management.