Disseminated infection with Scedosporium apiospermum is an emerging opportunistic infection in immunocompromised individuals. A 41-year-old male farmer presented with a diffuse swelling in the right foot with discharge of whitish material from the swelling for 1 year. He also had multiple cystic swellings of varying sizes in the right ankle, left leg, left foot, and right forearm for 6 months. There was a history of diabetes and steroid therapy for joint pain which had increased the risk of dissemination of fungi in our patient. Early recognition of this infection and treating the patients with systemic antifungal drugs such as voriconazole and local surgical debridement help in resolution of the lesion.