Abstract Behcet’s disease (BD) is a chronic relapsing and remitting autoinflammatory systemic vasculitis of unknown etiology. It affects almost all organs with its capacity to involve both arteries and veins of varying sizes, resulting in significant organ-threatening morbidity and mortality. Hereby, we report a case of a 40-year-old female, a known case of rheumatoid arthritis and hypothyroidism, who presented with right axillary abscess of size approximately 8 cm × 8 cm with multiple oral ulcers (OUs). She was hemodynamically stable. Systemic examination was normal. She had multiple aphthous ulcers in her mouth, associated with hemorrhagic crusting and superficial ulcers over cheeks as well as multiple painful genital ulcers. She also had a history of recurrent OUs in the past. A clinical diagnosis of BD was made. Human leukocyte antigen B serotype (HLA B 51) was positive. The axillary abscess was incised and drained. Antibiotics were upgraded as per sensitivity but the ulcer did not heal despite treatment. It worsened with each debridement, which could be explained by pathergy phenomenon.