The production, transport and integration of myelin components into the membrane during development is a highly coordinated and regulated process that relies heavily on the endoplasmic reticulum (ER), a sub-cellular organelle that is the principal site of membrane assembly. Ribosomes on the rough ER allow translation of proteins such as proteolipid protein (PLP) prior to correct folding, post-translational modification and eventual complexing with nascent smooth ER-synthesised lipids.