Nanotechnology is a new transnational and transcultural development that is growing rapidly and pervasively. The potential impact of novel Nanodentistry Applications in disease diagnosis, therapy and prevention is foreseen to change oral health care in a fundamental way. This review presents a general overview of the novel nanomaterial and relevant advances of nanotechnology, focusing on promising dental applications. In particular, relevant applications are reported in Restorative dentistry, minimally invasive dental procedures, cancer diagnosis and treatment, molecular imaging and implant dentistry. Many applications are still in their infancy. An increasing number of products are currently under clinical investigation while some are commercially available.