Light grey macules developed on the skin and in the mouths of juvenile caimans, (Caiman crocodilus fuscus) (n = 8), kept-in the quarantine section of the reptile park at the National Zoological Gardens, Pretoria, Republic of South Africa. The gross, histopathological and ultrastructural features of the lesions were commensurate with pox virus infection. This outbreak closely resembled the disease described elsewhere in 3 juvenile captive caimans.