Treatment of Wegener’s granulomatosis

descriptionPublicationkeyboard_double_arrow_right Article , Part of book or chapter of book 01 Jan 1993 Italy Publisher:PAGEPress PublicationsJournal:Reumatismo, volume 56 (issn: 0048-7449, eissn: 2240-2683,

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Authors: Lutz Briedigkeit; Marianne Ulmer; Ursula Göbel; Rudolf Natusch; Eva Reinhold-Keller; Wolfgang L. Gross;

doi: 10.4081/reumatismo.2004.69 , 10.1007/978-1-4757-9182-2_89

pmid: 8296663

handle: 11573/84989

Treatment of Wegener’s granulomatosis

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Abstract

Treatment and outcome of 111 patients who fell ill with Wegener's granulomatosis (WG) between 1966 and 1990 were analysed retrospectively. Two regimens of treatment were distinguished: "conventional" treatment, i.e. daily application of cyclophosphamide/corticosteroids (FAUCI scheme) or azathioprine/corticosteroids or corticosteroids alone, and "stage-adapted" treatment, characterized by change of different treatments (e.g. cyclophosphamide pulse therapy, cotrimoxazole) according to the extent and activity of disease. In patients who received stage-adapted treatment, exacerbations occurred significantly more frequent than in conventionally treated patients, while lethal outcome was much more frequent in conventionally treated patients.

Country

Italy

Related Organizations

Sapienza University of Rome
Italy
National Institute for Nuclear Physics
Italy
Roma Tre University
Italy
University of Lübeck
Germany

Keywords

Male, Remission Induction, R, Granulomatosis with Polyangiitis, Middle Aged, RC31-1245, Rheumatology, Adrenal Cortex Hormones, Azathioprine, Trimethoprim, Sulfamethoxazole Drug Combination, Medicine, Humans, Drug Therapy, Combination, Female, Internal medicine, Cyclophosphamide, Retrospective Studies

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