The general aim of this paper is to demonstrate that remote sensing techniques may easily provide the information needed for the application, over large areas, of agro-hydrological models for the actual evapotranspiration estimation. The application of the SEBAL model has been investigated at field scale and at district scale using highresolution hyperspectral (VIS/NIR + TIR) airborne data acquired in a Sicilian test area. In a first phase, SEBAL has been validated by means of scintillometer flux measurements. Then an application over a district area using MIVIS airborne data has been performed. The procedure provides the actual daily evapotranspiration distribution for a set of irrigated arboreous crops, confirming the potential advantage of this approach as an operative future tool useful to improve the efficiency of irrigation systems.