Enamel pearls are one of a number of different enamel structures that can be found on the roots of deciduous and permanent teeth. They have a distinct predilection for the furcation areas of molar, particularly the maxillary third and second molars. However, they have been found less commonly on the apical portions of the root. This report describes an unusual case of enamel pearl on apical third of mandibular molar teeth. Enamel pearl was confirmed as predisposing factor for the cause of localized periodontitis; it is very important to recognize their radiographic aspect to ensure proper treatment of involved teeth.