The Neutralization of Western Equine Encephalomyelitis Virus by Human Convalescent Serum. The Influence of Heat Labile Substances in Serum on the Neutralization Index

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1947 English Publisher:Oxford University Press (OUP)Journal:The Journal of Immunology, volume 56, pages 97-108 (issn: 0022-1767, eissn: 1550-6606,

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Authors: L, WHITMAN;

doi: 10.4049/jimmunol.56.2.97

pmid: 20240799

The Neutralization of Western Equine Encephalomyelitis Virus by Human Convalescent Serum. The Influence of Heat Labile Substances in Serum on the Neutralization Index

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Abstract

Summary Evidence is presented to show that a heat labile accessory substance which augments the activity of neutralizing antibodies to Western equine encephalomyelitis virus is present in normal serum. This substance loses most of its activity when diluted 1:10. Its possible relationship to complement and its bearing on diagnostic neutralization tests are discussed.

Keywords

Encephalomyelitis, Equine, Serum, Hot Temperature, Immune Sera, Animals, Humans, Encephalomyelitis, Western Equine, Horses, Encephalomyelitis, Encephalitis Virus, Western Equine

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