Detoxification of Crystalline Botulinum Type A Toxin

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1947 English Publisher:Oxford University Press (OUP)Journal:The Journal of Immunology, volume 55, pages 183-187 (issn: 0022-1767, eissn: 1550-6606,

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Authors: G A, HOTTLE; A, ABRAMS;

doi: 10.4049/jimmunol.55.2.183

pmid: 20285168

Detoxification of Crystalline Botulinum Type A Toxin

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Abstract

Summary Botulinum Type A toxoid has been prepared from crystalline toxin by the addition of formaldehyde. The most active preparation consisted of one component electrophoretically, immunized mice in a dose containing 0.01γ of toxoidnitrogen and was 2400 times more active antigenically than crude toxoid on the basis of nitrogen-content.

Keywords

Botulinum Toxins, Humans, Botulism, Botulinum Toxins, Type A

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