Thymocyte costimulating antigen is CD26 (dipeptidyl-peptidase IV). Costimulation of granulocyte, macrophage, and T lineage cell proliferation via CD26

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1992 English Publisher:Oxford University Press (OUP)Journal:The Journal of Immunology, volume 149, pages 367-372 (issn: 0022-1767, eissn: 1550-6606,

Copyright policy )

Authors: L A, Bristol; K, Sakaguchi; E, Appella; D, Doyle; L, Takács;

doi: 10.4049/jimmunol.149.2.367

pmid: 1352525

Thymocyte costimulating antigen is CD26 (dipeptidyl-peptidase IV). Costimulation of granulocyte, macrophage, and T lineage cell proliferation via CD26

- Summary
- Subjects
- Metrics

Abstract

Abstract The rat thymocyte costimulating protein appears to be involved in the regulation of CD4-/CD8- thymocyte proliferation in vitro. We show that thymocyte costimulating protein is dipeptidyl peptidase IV (E.C.N.3.4.14.5) also known as CD26. Some bone marrow cells as well as CD4-/CD8- and, and to a lesser extent, more differentiated T cells respond by proliferating to a CD26 specific mAb-mediated costimulus that does not influence dipeptidyl dipeptidase IV enzyme activity. This suggests the existence of a CD26-linked regulatory mechanism of proliferation that is operational on granulocyte- and macrophage-lineage cells and throughout T cell development.

Keywords

Antigens, Differentiation, T-Lymphocyte, Dipeptidyl Peptidase 4, T-Lymphocytes, Antibodies, Monoclonal, Macrophage Activation, Lymphocyte Activation, Rats, Inbred F344, Rats, Animals, Female, Rats, Inbred BUF, Granulocytes

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	33
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%