Human Immunoglobulin A: Production of an Fc Fragment by an Enteric Microbial Proteolytic Enzyme

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1973 English Publisher:Oxford University Press (OUP)Journal:The Journal of Immunology, volume 111, pages 1,274-1,276 (issn: 0022-1767, eissn: 1550-6606,

Authors: S K, Mehta; A G, Plaut; N J, Calvanico; T B, Tomasi;

doi: 10.4049/jimmunol.111.4.1274

pmid: 4199558

Human Immunoglobulin A: Production of an Fc Fragment by an Enteric Microbial Proteolytic Enzyme

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Abstract

Summary An Fc fragment has been prepared in good yield by proteolytic cleavage of human secretory and serum myeloma IgA with an enzyme recovered from the human gastrointestinal tract. The naturally occurring enzyme is of microbial origin and its activity is metal dependent.

Related Organizations

State University of New York at Potsdam
United States

Keywords

Immunoglobulins, Immunoglobulin A, Immunoglobulin Fc Fragments, Feces, Myeloma Proteins, Pronase, Escherichia coli, Humans, Bacillus subtilis, Peptide Hydrolases

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