Complement Fixation by Aggregated IgE through Alternate Pathway
Copyright policy )Complement Fixation by Aggregated IgE through Alternate Pathway
Summary Nonspecifically aggregated E myeloma protein fixed late component(s) of guinea pig and human C. Evidence was presented that the C fixation by the aggregate probably goes through an alternate pathway. Comparisons among aggregated Fc, aggregated F(ab′)2 and aggregated IgE with respect to the C-fixing activity showed that aggregated Fc had the highest C-fixing activity on a weight basis and indicated that structures essential for the reaction are present in the Fc portion of the molecules.
- Johns Hopkins University United States
- Good Samaritan Hospital United States
Biphenyl Compounds, Complement Fixation Tests, Guinea Pigs, Immunoglobulins, Complement System Proteins, Immunoglobulin E, Chromatography, DEAE-Cellulose, Pepsin A, Myeloma Proteins, Immunoglobulin G, Papain, Animals, Humans, Skin Tests
Biphenyl Compounds, Complement Fixation Tests, Guinea Pigs, Immunoglobulins, Complement System Proteins, Immunoglobulin E, Chromatography, DEAE-Cellulose, Pepsin A, Myeloma Proteins, Immunoglobulin G, Papain, Animals, Humans, Skin Tests
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