Abstract Horizontal well fracturing is a fundamental means of shale oil development. Due to the tight reservoir and difficulty in replenishing energy, horizontal well fracturing generally results in low production capacity, rapid decline, and low recovery rates. To accelerate shale oil development, it is necessary to develop fracturing technologies that increase production and recovery rates. The integration of terrestrial shale oil sources and reservoirs or the specific components in crude oil makes the reservoir more prone to oil wetting or complex wetting, which is not conducive to the extraction of crude oil. The extraction of movable crude oil can lead to rapid energy attenuation. The development direction of fracturing is to use tens of thousands of cubic meters of fracturing fluid to achieve deep matrix modification and energy replacement. In light of this, this paper proposed a new nano-emulsion fracturing fluid to enhance the stimulation effect. Based on the laboratory experiments, the interfacial activity, adsorption performance, wetting inversion, and spontaneous ambition of nano-emulsion were systematically evaluated.