This study investigates antecedents to and outcomes of two stress reactions, telework distress (detrimental stress), and telework eustress (beneficial stress) using a model derived from an integration of the transactional model of stress with the job-demands and resources model. The model includes a person antecedent (resilience), and three environment antecedents (work-family conflict, work overload, and autonomy). These factors should influence experienced distress and eustress, which, in turn, affect telework outcomes (telework satisfaction, exhaustion, perceived performance, and perceived productivity. The model is evaluated using a sample of 329 Chinese teleworkers. This study findings indicate that resilience, work-family conflict, and work overload affect experienced distress, while resilience and autonomy affect experienced eustress. Experienced distress influenced satisfaction, exhaustion, and perceived performance; eustress had effects on all four outcomes. Interestingly, resilience had the largest total effect sizes on telework outcomes.