Sustainable tourism implies preserved space, prevents ecological and socio-cultural devastation, but at the same time encourages tourism development. Their application and adequate implementation increases the chance of a tourist destination that will be able to develop sustainable tourism, so the aim of this paper is to separate characteristics and principles of sustainability on certain areas and to show their advantages and limitations. In this paper are introspected factors of tourism development, both in a positive and in a negative context. It was hypothesized that sustainable rural tourism in the Lower Danube region has a comparative advantage, but it is also a major challenge for the community. Methodological setting is qualitative, based on the contextual dimension of the data, empirical observations, exploratory research and observations. Obtained results show that the tourist offer of sustainable rural tourism in the Lower Danube region has its own unique values, which should continue to explore.