This chapter faces the Web accessibility issue from the perspective of Web Information Systems Quality, which is the main topic of the handbook. The closed relation between both issues (and also standard Web technologies) will be explained. It will be proven that Web accessibility does not imply any extra effort; it is a consequence of good development and design practices. In order to achieve this objective the basic topics related to Web accessibility will be defined and necessary introductory information will be exposed, in order to set the basis for the understanding of the points of discussion, which form the main content of the chapter. Also, some benefits of Web accessibility will be proven and the myths related to Web accessibility will be refuted. By the end of the chapter, the future trends and the newest standard Web technologies that have been designed, taking into account Web accessibility needs, will be introduced.