Aspochalasin I, a Melanogenesis Inhibitor from Aspergillus sp.
Copyright policy )Aspochalasin I, a Melanogenesis Inhibitor from Aspergillus sp.
In the course of screening for the melanogenesis inhibitors, aspochalasin I was isolated from solid-state culture of Aspergillus sp. Fb020460. Its structure was determined by spectroscopic analysis including mass spectroscopy and NMR analysis. Aspochalasin I potently inhibited melanogenesis in Mel-Ab cells with an IC50 value of 22.4 microM without cytotoxicity.
- Korea Research Institute of Bioscience and Biotechnology Korea (Republic of)
Melanins, Cell Survival, Monophenol Monooxygenase, Cytochalasins, Mass Spectrometry, Inhibitory Concentration 50, Mice, Aspergillus, Animals, Melanocytes, Nuclear Magnetic Resonance, Biomolecular, Cell Line, Transformed
Melanins, Cell Survival, Monophenol Monooxygenase, Cytochalasins, Mass Spectrometry, Inhibitory Concentration 50, Mice, Aspergillus, Animals, Melanocytes, Nuclear Magnetic Resonance, Biomolecular, Cell Line, Transformed
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