This article discusses the notion of the pluriverse based on a case study in the county of Cayambe, in the Ecuadorian Andes. It analyses how the first indigenous municipal administration in the history of the county (2014-2019) operated to promote a territoriality that evolves towards sumak kawsay, or living well, in the Kichwa language, and how plurinationality and interculturality have been enabling conditions for this. Based on the notion of an ecology of knowledge and practices in the pluriverse, it shows how the protagonists of this process, mostly indigenous, challenged anthropocentric modernity, while at the same time using or resignifying some of its tools or principles for their own ends.