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Journal of Clinical and Experimental Hematopathology
Article . 2019 . Peer-reviewed
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Journal of Clinical and Experimental Hematopathology
Article
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Journal of Clinical and Experimental Hematopathology
Article . 2020
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https://dx.doi.org/10.3960/jsl...
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Immune response in LPD during methotrexate administration (MTX-LPD) in rheumatoid arthritis patients

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 01 Jan 2019 English Publisher:Japanese Society for Lymphoreticular Tissue ResearchJournal:Journal of Clinical and Experimental Hematopathology, volume 59, pages 145-155 (issn: 1346-4280, eissn: 1880-9952, Copyright policy )
Authors: Saito, Shuntaro; Takeuchi, Tsutomu;

doi: 10.3960/jslrt.19028

pmid: 31866617

pmc: PMC6954173

Immune response in LPD during methotrexate administration (MTX-LPD) in rheumatoid arthritis patients

Abstract

Methotrexate (MTX) is known as a first-line synthetic disease-modifying anti-rheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Although the risk of LPD development increases by RA inflammation itself, observation of spontaneous regression of LPD after MTX discontinuation lead to the theory of lymphomagenic role of MTX. In this review, we focused on the several immune response involved in LPD that developed under MTX administration in RA patients.

Related Organizations
Keywords

Arthritis, Rheumatoid, Methotrexate, Antirheumatic Agents, Humans, Review Article, Lymphoproliferative Disorders

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
26
Top 10%
Top 10%
Top 10%
Green
gold