An algorithm for managing warfarin resistance

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2009 English Publisher:Cleveland Clinic Journal of MedicineJournal:Cleveland Clinic Journal of Medicine, volume 76, pages 724-730 (issn: 0891-1150, eissn: 1939-2869,

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Authors: Olusegun, Osinbowale; Monzr, Al Malki; Andrew, Schade; John R, Bartholomew;

doi: 10.3949/ccjm.76a.09062

pmid: 19952297

An algorithm for managing warfarin resistance

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Abstract

Some patients need higher-than-expected doses of warfarin (Coumadin) to get their international normalized ratio (INR) into the therapeutic range. The cause of warfarin resistance can be either acquired (eg, poor compliance, drug interactions, dietary interactions) or hereditary, but the genetic mechanisms of warfarin resistance are not well understood. This review offers an algorithm for the evaluation of patients with suspected warfarin resistance.

Related Organizations

Boston University
United States
Cleveland Clinic
United States
Roger Williams Medical Center
United States
Boston College
United States

Keywords

Dose-Response Relationship, Drug, Drug Resistance, Anticoagulants, Humans, Warfarin, Drug Monitoring, Algorithms

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