<P>A 61-year-old woman presented with photophobia, pain, epiphora, and decreased vision as a result of two iatrogenic corneal perforations sustained during carbon dioxide laser blepharoplasty. The management and course of the case are outlined. Laser blepharoplasty complications are reviewed. This case highlights the potential occurrence of corneal penetration with laser blepharoplasty. Meticulous awareness of the laser effects on periocular tissue must be kept in mind at all times during laser blepharoplasty to avoid unnecessary intraocular side effects and undesirable postoperative outcomes. [<CITE>Ophthalmic Surg Lasers Imaging</CITE> 2006;37:327-329.]</P> <H4>AUTHORS</H4> <P>From the Department of Ophthalmology (JKD, IRS), University of California—Davis, Sacramento, California; and Eye Consultants of Atlanta (WBL), Atlanta, Georgia.</P> <P>Dr. Schwab is supported in part by an unrestricted grant from Research to Prevent Blindness, Inc., New York, New York.</P> <P>Accepted for publication April 10, 2006.</P> <P>Address reprint requests to W. Barry Lee, MD, 95 Collier Road, Suite 3000, Atlanta, GA 30309.</P>