Two new species of Columnea are described based on recent field expeditions and herbarium research. These species are unusual within Columnea for exhibiting a dorsiventral epiphytic habit typical of many northern Andean species, but they lack conspicuous floral bracts. Columnea combeimae Lozano-Cif., J.E.Ríos & J.L.Clark, sp. nov. is distinguished by uniformly green leaves, prominent extrafloral nectary glands on the pedicels, and a hirsute indumentum of purple trichomes. Columnea rubropilosa J.L.Clark & Clavijo, sp. nov. is characterized by a conic purple berry and a densely pilose indumentum of red trichomes on both vegetative and reproductive structures. Both species are endemic to the Colombian Andes.