Hypericum shunhuangshanense, a new species of Hypericaceae from the Shunhuangshan National Nature Reserve in Hunan Province, China, is described and illustrated, based on morphological and molecular phylogenetic evidence. The new species resembles H. faberi in morphology but clusters with H. seniawinii in phylogenetic analyses; it can be easily distinguished from both by its leaves sessile and decussate, inflorescence cymose, anthers yellow to deep orange, and locules 3.