Cdc6 expression as a marker of proliferative activity in brain tumors
Copyright policy )Cdc6 expression as a marker of proliferative activity in brain tumors
Antibodies against human proteins that regulate DNA replication such as Cdc6 and Mcm5 became available as a new marker of proliferation. We performed immunohistochemical analysis with MIB-1 and antibody against Cdc6 on 35 brain tumors, including tumors of neuroepithelial tissue, vestibular schwannomas, meningiomas, and pituitary adenomas. Median reactivity for MIB-1 was 8.8%, and that for Cdc6 was 55%. Reactivity in most brain tumors was significantly higher for Cdc6 than for MIB-1, but reactivity of Cdc6 was independent of tumor grade. Detection of Cdc6 expression might be useful for the estimation of proliferative activity in brain tumors.
Male, Brain Neoplasms, Nuclear Proteins, Antigens, Nuclear, Cell Cycle Proteins, Middle Aged, Prognosis, Survival Analysis, Immunoenzyme Techniques, Ki-67 Antigen, Biomarkers, Tumor, Humans, Female
Male, Brain Neoplasms, Nuclear Proteins, Antigens, Nuclear, Cell Cycle Proteins, Middle Aged, Prognosis, Survival Analysis, Immunoenzyme Techniques, Ki-67 Antigen, Biomarkers, Tumor, Humans, Female
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