When effective anti-cancer drugs first became available to clinicians they were commonly used by surgeons by intra-arterial infusion to treat difficult regional cancer problems. Because they were most often used to treat poorly vascularised recurrent cancers results were, in general, unsatisfactory. The intra-arterial approach fell into disrepute and continued use of these techniques has often been criticised and results achieved treated with scepticism. Reasons for the original poor results are now well understood and techniques for effective and safe regional chemotherapy have been developed. These techniques of regional chemotherapy, when appropriately used especially as induction treatment, have an important role to play in a comprehensive oncology therapeutic service. However the criticisms and reluctance to accept the use of chemotherapy on a regional basis remain widespread. Some of the objections and difficulties expressed are valid but some are quite invalid and indicate reluctance to review the situation in spite of valuable progress and understanding and in spite of important clinical applications. Outlined in this review are valid objections, including increased facilities and skills needed and their cost, as well as invalid objections based on misconceptions, inexperience and reluctance to review or accept need for change of familiar practices.