Ectopic expression of DICE1 suppresses tumor cell growth
Copyright policy )Ectopic expression of DICE1 suppresses tumor cell growth
The tumor suppressor gene DICE1 is located within a previously reported critical region of loss of heterozygosity on chromosome 13q14.3. Expression of the remaining DICE1 allele is down-regulated in non-small cell lung carcinomas. Ectopic expression of DICE1 cDNA by DICE1-green fluorescent protein fusion constructs resulted in inhibition of colony formation of human non-small cell lung carcinoma cell line SK-MES-1 and NCI-H520 and prostate carcinoma cell line DU145. In IGF-IR transformed Balb/c 3T3, DICE1 substantially sup-pressed growth in soft agar. These results demonstrate that DICE1 has a growth-suppressing activity and interferes with anchorage-independent growth of IGF-IR transformed tumor cells dependent upon IGF-I signaling.
- Institut für Humangenetik Germany
- Otto-von-Guericke University Magdeburg Germany
Mice, Inbred BALB C, DNA, Complementary, Amino Acid Motifs, Green Fluorescent Proteins, RNA-Binding Proteins, Exons, Blotting, Northern, Agar, Mice, Cell Line, Tumor, Neoplasms, Animals, Humans, RNA, Genes, Tumor Suppressor, RNA, Messenger, Insulin-Like Growth Factor I, RNA Helicases, Cell Proliferation, Plasmids
Mice, Inbred BALB C, DNA, Complementary, Amino Acid Motifs, Green Fluorescent Proteins, RNA-Binding Proteins, Exons, Blotting, Northern, Agar, Mice, Cell Line, Tumor, Neoplasms, Animals, Humans, RNA, Genes, Tumor Suppressor, RNA, Messenger, Insulin-Like Growth Factor I, RNA Helicases, Cell Proliferation, Plasmids
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