Brca1 and Brca2 protein expression patterns in different tissues of murine origin

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2001Publisher:Spandidos PublicationsJournal:International Journal of Oncology (issn: 1019-6439, eissn: 1791-2423,

Copyright policy )

Authors: D J, Bernard-Gallon; M P, De Latour; V, Sylvain; C, Vissac; B, Aunoble; J, Chassagne; Y J, Bignon;

doi: 10.3892/ijo.18.2.271

pmid: 11172592

Brca1 and Brca2 protein expression patterns in different tissues of murine origin

- Summary
- Subjects
- Metrics

Abstract

We have analyzed by immunohistochemistry Brca1 and Brca2 protein expression in mouse during embryonic development, in adult tissues, and during postnatal mammary gland development. Our observations confirm previous localization of Brca1 and Brca2 mRNA on frozen sections by in situ hybridization, and demonstrate that Brca1 and Brca2 proteins are expressed in rapidly proliferating cell types undergoing differentiation. These results imply that Brca1 and Brca2 proteins are involved in the process of proliferation and differentiation in multiple tissues, notably in the mammary gland during pregnancy and lactation.

Related Organizations

Centre Jean Perrin
France

Keywords

BRCA2 Protein, BRCA1 Protein, Brain, Immunohistochemistry, Neoplasm Proteins, Mice, Inbred C57BL, Embryonic and Fetal Development, Mice, Mammary Glands, Animal, Pregnancy, Animals, Female, Transcription Factors

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	11
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average