Efavirenz Intoxication Due to a New Cyp2B6 Constellation
Copyright policy )Efavirenz Intoxication Due to a New Cyp2B6 Constellation
Here, we describe severe neuropsychiatric symptoms in an HIV-positive Asian man with extremely high efavirenz plasma levels while receiving standard treatment with efavirenz/tenofovir/emtricitabine fixed-dose regimen. Genetic examination revealed compound homozygosity for loss-of-function alleles of CYP2B6, including coding for a rare truncated protein. Neuropsychiatric symptoms resolved completely after efavirenz discontinuation.
- University of Zurich Switzerland
- University of Lausanne Switzerland
- Institute of Microbiology Switzerland
- University Hospital of Lausanne Switzerland
- Hôpital de Sion Switzerland
Adult, Cyclopropanes, Male, Genotype, Anti-HIV Agents, 610 Medicine & health, HIV Infections, 2725 Infectious Diseases, Polymorphism, Single Nucleotide, Benzoxazines, 10234 Clinic for Infectious Diseases, Cytochrome P-450 CYP2B6, 3004 Pharmacology, Pharmacogenetics, Alkynes, HIV-1, 2736 Pharmacology (medical), Humans, Reverse Transcriptase Inhibitors, Aryl Hydrocarbon Hydroxylases, Alleles
Adult, Cyclopropanes, Male, Genotype, Anti-HIV Agents, 610 Medicine & health, HIV Infections, 2725 Infectious Diseases, Polymorphism, Single Nucleotide, Benzoxazines, 10234 Clinic for Infectious Diseases, Cytochrome P-450 CYP2B6, 3004 Pharmacology, Pharmacogenetics, Alkynes, HIV-1, 2736 Pharmacology (medical), Humans, Reverse Transcriptase Inhibitors, Aryl Hydrocarbon Hydroxylases, Alleles
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